2531.25% is the change from 16 to 421
Calculation steps:
[( 421 - 16 ) ÷ 16] x 100 = 2531.25%
Formula
Percentage change = [(421 - 16) / 16] x 100
Subtract the new number by the original number
421 - 16 = 405
405 ÷ 16 = 25.3125
25.3125 x 100 = 2531.25%