-10.21% is the change from 421 to 378
Calculation steps:
[( 378 - 421 ) ÷ 421] x 100 = -10.21%
Formula
Percentage change = [(378 - 421) / 421] x 100
Subtract the new number by the original number
378 - 421 = -43
-43 ÷ 421 = -0.1021377672209026
-0.1021377672209026 x 100 = -10.21%