53.44% is the change from 421 to 646
Calculation steps:
[( 646 - 421 ) ÷ 421] x 100 = 53.44%
Formula
Percentage change = [(646 - 421) / 421] x 100
Subtract the new number by the original number
646 - 421 = 225
225 ÷ 421 = 0.5344418052256532
0.5344418052256532 x 100 = 53.44%